Provocation test in patients with different phenotypes of aspirin hypersensitivity

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Provocation test in patients with different phenotypes of aspirin hypersensitivity

Background Aspirin (ASA) hypersensitivity has a complex clinical presentation with three major phenotypes: aspirinexacerbated respiratory disease (AERD; asthma and/or nasal polyps), chronic urticaria and aspirin-induced anaphylaxis. In patients with AERD asthma is often severe and difficult to control. Moreover, NSAID ingestion may provoke life-threatening attack. Thus, diagnosing of ASA hypers...

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EAACI/GA2LEN guideline: aspirin provocation tests for diagnosis of aspirin hypersensitivity.

Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most common causes of adverse drug reactions. Majority of them are of the hypersensitivity type. The two frequent clinical presentations of aspirin hypersensitivity are: aspirin-induced bronchial asthma/rhinosinusitis (AIA/R) and aspirin-induced urticaria/angioedema (AIU). The decisive diagnosis is based on provocatio...

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The values of nasal provocation test and basophil activation test in the different patterns of ASA/NSAID hypersensitivity.

BACKGROUND The oral provocation test (OPT) is the current gold standard to diagnose aspirin hypersensitivity syndrome although it is time-consuming and contains some systemic risks. Other reliable methods with lower side effects and shorter test duration are being investigated. OBJECTIVE The purpose of this study was to evaluate the efficacy of the nasal provocation test (NPT) and the basophi...

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ژورنال

عنوان ژورنال: Clinical and Translational Allergy

سال: 2013

ISSN: 2045-7022,2045-7022

DOI: 10.1186/2045-7022-3-s1-p8